Search results for "Zona incerta"
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The zona incerta system: Involvement in attention and movement
2021
The zona incerta (ZI) is a large structure made of four neurochemically defined regions (at least, in rodents). It is globally involved in complex connections with telencephalic and brainstem centers. In this work, we focus on some of the anatomical links this structure develops with the cerebral cortex and the tectum. We also point to its integration within a larger basal ganglia network. The functions of this region are still mysterious, even if recent works suggest its participation in behavioral expression. Studies about the functional organization of the vibrissal system have provided the first integrated model, illustrating the ZI's role in sensory-motor programing. In addition, ZI co…
Distribution of bradykinin B2 receptors in sheep brain and spinal cord visualized by in vitro autoradiography
1997
Bradykinin B2 receptors were localized in the sheep brain and spinal cord by quantitative in vitro autoradiography using a radiolabelled and specific bradykinin B2 receptor antagonist analogue, 3-4-hydroxyphenyl-propionyl-D-Arg0-[Hyp3,Thi5,D-Tic 7,Oic8]bradykinin, (HPP-HOE 140). This radioligand displays high affinity and specificity for bradykinin B2 receptors. The respective K(i) values of 0.32, 1.37 and 156 nM were obtained for bradykinin, HOE140 and D-Arg[Hyp3,D-Phe7,Leu8]bradykinin competing for radioligand binding to lamina II of sheep spinal cord sections. Using this radioligand, we have demonstrated the distribution of bradykinin B2 receptors in many brain regions which have not bee…